Decken, Cay-Benedict; Kleinert, Stefan; Englbrecht, Matthias; Karberg, Kirsten; Gauler, Georg; Ronneberger, Monika; Rapp, Praxedis; Schuch, Florian; Wendler, Joerg; Späthling-Mestekemper, Susanna; Kuhn, Christoph; Vorbrüggen, Wolfgang; Welcker, Martin; Bartz-Bazzanella, Peter: RhePort 1.3 enhances early identification of inflammatory rheumatic diseases: a prospective study in German rheumatology settings. In: Rheumatol Int, Bd. 45, Nr. 5, S. 129, 2025, ISSN: 1437-160X. @article{pmid40293492,
title = {RhePort 1.3 enhances early identification of inflammatory rheumatic diseases: a prospective study in German rheumatology settings},
author = {Cay-Benedict Decken and Stefan Kleinert and Matthias Englbrecht and Kirsten Karberg and Georg Gauler and Monika Ronneberger and Praxedis Rapp and Florian Schuch and Joerg Wendler and Susanna Späthling-Mestekemper and Christoph Kuhn and Wolfgang Vorbrüggen and Martin Welcker and Peter Bartz-Bazzanella},
doi = {10.1007/s00296-025-05861-z},
issn = {1437-160X},
year = {2025},
date = {2025-04-01},
journal = {Rheumatol Int},
volume = {45},
number = {5},
pages = {129},
abstract = {More efficient means of identifying patients with inflammatory rheumatic diseases (IRDs) could allow earlier diagnosis and treatment. The objective of this study was to evaluate the characteristics of a revised version of an online patient questionnaire-based self-referral tool, RhePort 1.3. This prospective study included adult patients with musculoskeletal complaints presenting for a first rheumatology visit at German RheumaDatenRhePort (RHADAR) rheumatology network centers. All patients completed the RhePort 1.3 questionnaire on patient characteristics and symptoms. Data from RhePort 1.3 were compared with historical data from previous versions. Of 614 patients, 225 (36.6%) were diagnosed with an IRD by a rheumatologist and 164/225 IRD patients (72.9%) had a RhePort 1.3 score > 1, the cut-off point used to determine the need for rheumatologic evaluation. A score > 1 was associated with an approximately two-fold higher IRD risk (odds ratio [95% confidence interval] of 1.98 [1.39, 2.83] vs ≤ 1) and had good sensitivity (73%) and moderate specificity (42%). Among patients referred through a standard referral pathway (n = 283), RhePort 1.3 scores > 1 in addition to physician referral were associated with increases in rheumatology-diagnosed IRD rates from 33.2% (physician referral only) to 45.7%. RhePort 1.3 had higher accuracy than earlier versions (54% vs 35%). We conclude that modest changes to the RhePort questionnaire resulted in increased accuracy. A score > 1 was associated with a doubled risk for an IRD and higher IRD rates in physician-referred patients. These data suggest that RhePort has the potential to streamline the rheumatologist's workload and improve resource use. Further modifications are required to improve specificity.},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
More efficient means of identifying patients with inflammatory rheumatic diseases (IRDs) could allow earlier diagnosis and treatment. The objective of this study was to evaluate the characteristics of a revised version of an online patient questionnaire-based self-referral tool, RhePort 1.3. This prospective study included adult patients with musculoskeletal complaints presenting for a first rheumatology visit at German RheumaDatenRhePort (RHADAR) rheumatology network centers. All patients completed the RhePort 1.3 questionnaire on patient characteristics and symptoms. Data from RhePort 1.3 were compared with historical data from previous versions. Of 614 patients, 225 (36.6%) were diagnosed with an IRD by a rheumatologist and 164/225 IRD patients (72.9%) had a RhePort 1.3 score > 1, the cut-off point used to determine the need for rheumatologic evaluation. A score > 1 was associated with an approximately two-fold higher IRD risk (odds ratio [95% confidence interval] of 1.98 [1.39, 2.83] vs ≤ 1) and had good sensitivity (73%) and moderate specificity (42%). Among patients referred through a standard referral pathway (n = 283), RhePort 1.3 scores > 1 in addition to physician referral were associated with increases in rheumatology-diagnosed IRD rates from 33.2% (physician referral only) to 45.7%. RhePort 1.3 had higher accuracy than earlier versions (54% vs 35%). We conclude that modest changes to the RhePort questionnaire resulted in increased accuracy. A score > 1 was associated with a doubled risk for an IRD and higher IRD rates in physician-referred patients. These data suggest that RhePort has the potential to streamline the rheumatologist's workload and improve resource use. Further modifications are required to improve specificity. |
Kleinert, S.; Schuch, F.; Rapp, P.; Ronneberger, M.; Wendler, J.; Sternad, P.; Popp, F.; Bartz-Bazzanella, P.; Decken, C.; Karberg, K.; Gauler, G.; Wurth, P.; Spathling-Mestekemper, S.; Kuhn, C.; Vorbruggen, W.; Welcker, M.: Radiographic and non-radiographic axial spondyloarthritis are not routinely distinguished in everyday clinical care: an analysis of real-world data from rheumatology practices. In: Rheumatol Int, Bd. 44, Nr. 4, S. 653-661, 2024, ISSN: 1437-160X (Electronic)
0172-8172 (Linking). @article{RN10322b,
title = {Radiographic and non-radiographic axial spondyloarthritis are not routinely distinguished in everyday clinical care: an analysis of real-world data from rheumatology practices},
author = {S. Kleinert and F. Schuch and P. Rapp and M. Ronneberger and J. Wendler and P. Sternad and F. Popp and P. Bartz-Bazzanella and C. Decken and K. Karberg and G. Gauler and P. Wurth and S. Spathling-Mestekemper and C. Kuhn and W. Vorbruggen and M. Welcker},
url = {https://www.ncbi.nlm.nih.gov/pubmed/37805981},
doi = {10.1007/s00296-023-05463-7},
issn = {1437-160X (Electronic)
0172-8172 (Linking)},
year = {2024},
date = {2024-01-01},
journal = {Rheumatol Int},
volume = {44},
number = {4},
pages = {653-661},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
|
Stephan, Marlene; Tascilar, Koray; Yalcin-Mutlu, Melek; Hagen, Melanie; Haschka, Judith; Reiser, Michaela; Hartmann, Fabian; Kleyer, Arnd; Hueber, Axel J; Manger, Bernhard; Figueiredo, Camille; Cobra, Jayme Fogagnolo; Tony, Hans-Peter; Finzel, Stephanie; Kleinert, Stefan; Wendler, Jörg; Schuch, Florian; Ronneberger, Monika; Feuchtenberger, Martin; Fleck, Martin; Manger, Karin; Ochs, Wolfgang; Schmitt-Haendle, Matthias; Lorenz, Hannes Martin; Nüsslein, Hubert; Alten, Rieke; Henes, Joerg; Krüger, Klaus; Schett, Georg; Rech, Jürgen: Physical Function of RA patients Tapering Treatment-A Post Hoc Analysis of the Randomized Controlled RETRO Trial. In: J Clin Med, Bd. 12, Nr. 11, 2023, ISSN: 2077-0383. @article{pmid37297917,
title = {Physical Function of RA patients Tapering Treatment-A Post Hoc Analysis of the Randomized Controlled RETRO Trial},
author = {Marlene Stephan and Koray Tascilar and Melek Yalcin-Mutlu and Melanie Hagen and Judith Haschka and Michaela Reiser and Fabian Hartmann and Arnd Kleyer and Axel J Hueber and Bernhard Manger and Camille Figueiredo and Jayme Fogagnolo Cobra and Hans-Peter Tony and Stephanie Finzel and Stefan Kleinert and Jörg Wendler and Florian Schuch and Monika Ronneberger and Martin Feuchtenberger and Martin Fleck and Karin Manger and Wolfgang Ochs and Matthias Schmitt-Haendle and Hannes Martin Lorenz and Hubert Nüsslein and Rieke Alten and Joerg Henes and Klaus Krüger and Georg Schett and Jürgen Rech},
doi = {10.3390/jcm12113723},
issn = {2077-0383},
year = {2023},
date = {2023-05-01},
journal = {J Clin Med},
volume = {12},
number = {11},
abstract = {Several studies have shown that tapering or stopping disease-modifying anti-rheumatic drugs (DMARDs) in rheumatoid arthritis (RA) patients in sustained remission is feasible. However, tapering/stopping bears the risk of decline in physical function as some patients may relapse and face increased disease activity. Here, we analyzed the impact of tapering or stopping DMARD treatment on the physical function of RA patients. The study was a post hoc analysis of physical functional worsening for 282 patients with RA in sustained remission tapering and stopping DMARD treatment in the prospective randomized RETRO study. HAQ and DAS-28 scores were determined in baseline samples of patients continuing DMARD (arm 1), tapering their dose by 50% (arm 2), or stopping after tapering (arm 3). Patients were followed over 1 year, and HAQ and DAS-28 scores were evaluated every 3 months. The effect of treatment reduction strategy on functional worsening was assessed in a recurrent-event Cox regression model with a study-group (control, taper, and taper/stop) as the predictor. Two-hundred and eighty-two patients were analyzed. In 58 patients, functional worsening was observed. The incidences suggest a higher probability of functional worsening in patients tapering and/or stopping DMARDs, which is likely due to higher relapse rates in these individuals. At the end of the study, however, functional worsening was similar among the groups. Point estimates and survival curves show that the decline in functionality according to HAQ after tapering or discontinuation of DMARDs in RA patients with stable remission is associated with recurrence, but not with an overall functional decline.},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Several studies have shown that tapering or stopping disease-modifying anti-rheumatic drugs (DMARDs) in rheumatoid arthritis (RA) patients in sustained remission is feasible. However, tapering/stopping bears the risk of decline in physical function as some patients may relapse and face increased disease activity. Here, we analyzed the impact of tapering or stopping DMARD treatment on the physical function of RA patients. The study was a post hoc analysis of physical functional worsening for 282 patients with RA in sustained remission tapering and stopping DMARD treatment in the prospective randomized RETRO study. HAQ and DAS-28 scores were determined in baseline samples of patients continuing DMARD (arm 1), tapering their dose by 50% (arm 2), or stopping after tapering (arm 3). Patients were followed over 1 year, and HAQ and DAS-28 scores were evaluated every 3 months. The effect of treatment reduction strategy on functional worsening was assessed in a recurrent-event Cox regression model with a study-group (control, taper, and taper/stop) as the predictor. Two-hundred and eighty-two patients were analyzed. In 58 patients, functional worsening was observed. The incidences suggest a higher probability of functional worsening in patients tapering and/or stopping DMARDs, which is likely due to higher relapse rates in these individuals. At the end of the study, however, functional worsening was similar among the groups. Point estimates and survival curves show that the decline in functionality according to HAQ after tapering or discontinuation of DMARDs in RA patients with stable remission is associated with recurrence, but not with an overall functional decline. |
Kleinert, Stefan; Rapp, Praxedis; Schuch, Florian; Ronneberger, Monika; Wendler, Joerg; Sternad, Patrizia; Popp, Florian; Bartz-Bazzanella, Peter; Decken, Cay; Karberg, Kirsten; Gauler, Georg; Wurth, Patrick; Späthling-Mestekemper, Susanna; Kuhn, Christoph; Vorbrüggen, Wolfgang; Welcker, Martin: Röntgenologische versus non-röntgenologische axiale Spondyloarthritis - Auch ein Real-World-Klassifikation. In: Deutscher Rheumatologiekongress 2023, 51. Kongress der Deutschen Gesellschaft für Rheumatologie (DGRh), 2023. @article{RN10244,
title = {Röntgenologische versus non-röntgenologische axiale Spondyloarthritis - Auch ein Real-World-Klassifikation},
author = {Stefan Kleinert and Praxedis Rapp and Florian Schuch and Monika Ronneberger and Joerg Wendler and Patrizia Sternad and Florian Popp and Peter Bartz-Bazzanella and Cay Decken and Kirsten Karberg and Georg Gauler and Patrick Wurth and Susanna Späthling-Mestekemper and Christoph Kuhn and Wolfgang Vorbrüggen and Martin Welcker},
doi = {https://dx.doi.org/10.3205/23dgrh184},
year = {2023},
date = {2023-01-01},
journal = {Deutscher Rheumatologiekongress 2023, 51. Kongress der Deutschen Gesellschaft für Rheumatologie (DGRh)},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
|
Kleinert, S.; Schuch, F.; Rapp, P.; Ronneberger, M.; Wendler, J.; Sternad, P.; Popp, F.; Bartz-Bazzanella, P.; Decken, C.; Karberg, K.; Gauler, G.; Wurth, P.; Spathling-Mestekemper, S.; Kuhn, C.; Englbrecht, M.; Vorbruggen, W.; Adler, G.; Welcker, M.: Impairment in cognitive function in patients with axial spondyloarthritis and psoriatic arthritis. In: Rheumatol Int, Bd. 43, Nr. 1, S. 89-97, 2023, ISSN: 1437-160X (Electronic)
0172-8172 (Linking). @article{RN10032,
title = {Impairment in cognitive function in patients with axial spondyloarthritis and psoriatic arthritis},
author = {S. Kleinert and F. Schuch and P. Rapp and M. Ronneberger and J. Wendler and P. Sternad and F. Popp and P. Bartz-Bazzanella and C. Decken and K. Karberg and G. Gauler and P. Wurth and S. Spathling-Mestekemper and C. Kuhn and M. Englbrecht and W. Vorbruggen and G. Adler and M. Welcker},
url = {https://www.ncbi.nlm.nih.gov/pubmed/36441274},
doi = {10.1007/s00296-022-05248-4},
issn = {1437-160X (Electronic)
0172-8172 (Linking)},
year = {2023},
date = {2023-01-01},
journal = {Rheumatol Int},
volume = {43},
number = {1},
pages = {89-97},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
|
Kleinert, S.; Burigk, K.; Baltrusch, S.; Ronneberger, M.; Rapp, P.; Wendler, J.; Schuch, F.; Welcker, M.; Decken, C.; Bartz-Bazzanella, P.; Vorbrüggen, W.: RhePORT – Effizienz hinsichtlich personeller Ressourcen und Patientenselektion – Bewährung im Praxisalltag!. In: Deutscher Rheumatologiekongress 2023, 51. Kongress der Deutschen Gesellschaft für Rheumatologie (DGRh), 2023. @article{RN10245,
title = {RhePORT – Effizienz hinsichtlich personeller Ressourcen und Patientenselektion – Bewährung im Praxisalltag!},
author = {S. Kleinert and K. Burigk and S. Baltrusch and M. Ronneberger and P. Rapp and J. Wendler and F. Schuch and M. Welcker and C. Decken and P. Bartz-Bazzanella and W. Vorbrüggen},
doi = {https://dx.doi.org/10.3205/23dgrh236},
year = {2023},
date = {2023-01-01},
journal = {Deutscher Rheumatologiekongress 2023, 51. Kongress der Deutschen Gesellschaft für Rheumatologie (DGRh)},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
|
Stephan, M.; Tascilar, K.; Yalcin-Mutlu, M.; Hagen, M.; Haschka, J.; Reiser, M.; Hartmann, F.; Kleyer, A.; Hueber, A. J.; Manger, B.; Figueiredo, C.; Cobra, J. F.; Tony, H. P.; Finzel, S.; Kleinert, S.; Wendler, J.; Schuch, F.; Ronneberger, M.; Feuchtenberger, M.; Fleck, M.; Manger, K.; Ochs, W.; Schmitt-Haendle, M.; Lorenz, H. M.; Nüsslein, H.; Alten, R.; Henes, J.; Krüger, K.; Schett, G.; Rech, J.: Physical Function of RA patients Tapering Treatment-A Post Hoc Analysis of the Randomized Controlled RETRO Trial. In: J Clin Med, Bd. 12, Nr. 11, 2023, ISSN: 2077-0383 (Print)
2077-0383. @article{RN10321,
title = {Physical Function of RA patients Tapering Treatment-A Post Hoc Analysis of the Randomized Controlled RETRO Trial},
author = {M. Stephan and K. Tascilar and M. Yalcin-Mutlu and M. Hagen and J. Haschka and M. Reiser and F. Hartmann and A. Kleyer and A. J. Hueber and B. Manger and C. Figueiredo and J. F. Cobra and H. P. Tony and S. Finzel and S. Kleinert and J. Wendler and F. Schuch and M. Ronneberger and M. Feuchtenberger and M. Fleck and K. Manger and W. Ochs and M. Schmitt-Haendle and H. M. Lorenz and H. Nüsslein and R. Alten and J. Henes and K. Krüger and G. Schett and J. Rech},
doi = {10.3390/jcm12113723},
issn = {2077-0383 (Print)
2077-0383},
year = {2023},
date = {2023-01-01},
journal = {J Clin Med},
volume = {12},
number = {11},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
|
Kleinert, S.; Schuch, F.; Rapp, P.; Ronneberger, M.; Wendler, J.; Sternad, P.; Popp, F.; Bartz-Bazzanella, P.; Decken, C.; Karberg, K.; Gauler, G.; Wurth, P.; Spathling-Mestekemper, S.; Kuhn, C.; Vorbruggen, W.; Welcker, M.: Radiographic and non-radiographic axial spondyloarthritis are not routinely distinguished in everyday clinical care: an analysis of real-world data from rheumatology practices. In: Rheumatol Int, 2023, ISSN: 1437-160X (Electronic) 0172-8172 (Linking). @article{RN10322,
title = {Radiographic and non-radiographic axial spondyloarthritis are not routinely distinguished in everyday clinical care: an analysis of real-world data from rheumatology practices},
author = {S. Kleinert and F. Schuch and P. Rapp and M. Ronneberger and J. Wendler and P. Sternad and F. Popp and P. Bartz-Bazzanella and C. Decken and K. Karberg and G. Gauler and P. Wurth and S. Spathling-Mestekemper and C. Kuhn and W. Vorbruggen and M. Welcker},
url = {https://www.ncbi.nlm.nih.gov/pubmed/37805981},
doi = {10.1007/s00296-023-05463-7},
issn = {1437-160X (Electronic) 0172-8172 (Linking)},
year = {2023},
date = {2023-01-01},
urldate = {2023-01-01},
journal = {Rheumatol Int},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
|
Hoeper, Juliana Rachel; Zeidler, Jan; Meyer, Sara Eileen; Gauler, Georg; Steffens-Korbanka, Patricia; Welcker, Martin; Wendler, Jörg; Schuch, Florian; Hinüber, Ulrich; Schwarting, Andreas; Witte, Torsten; Meyer-Olson, Dirk; Hoeper, Kirsten: Effect of nurse-led care on outcomes in patients with
ACPA/RF-positive rheumatoid arthritis with active disease
undergoing treat-to-target: a multicentre randomised controlled
trial. In: RMD Open, Bd. 7, Nr. 1, S. e001627, 2021. @article{Hoeper2021-nl,
title = {Effect of nurse-led care on outcomes in patients with
ACPA/RF-positive rheumatoid arthritis with active disease
undergoing treat-to-target: a multicentre randomised controlled
trial},
author = {Juliana Rachel Hoeper and Jan Zeidler and Sara Eileen Meyer and Georg Gauler and Patricia Steffens-Korbanka and Martin Welcker and Jörg Wendler and Florian Schuch and Ulrich Hinüber and Andreas Schwarting and Torsten Witte and Dirk Meyer-Olson and Kirsten Hoeper},
year = {2021},
date = {2021-04-01},
journal = {RMD Open},
volume = {7},
number = {1},
pages = {e001627},
publisher = {BMJ},
abstract = {ÖBJECTIVE: To determine the non-inferiority of nurse-led care
(NLC) in patients with anticitrullinated protein antibody
(ACPA)-positive and/or rheumatoid factor (RF)-positive
rheumatoid arthritis (RA) with active disease who are starting
disease-modifying antirheumatic drug therapy, following
treat-to-target (T2T) recommendations. METHODS: A multicentre,
pragmatic randomised controlled trial was conducted to assess
clinical effectiveness, anxiety, depression and patient
satisfaction following a non-inferiority design. The
participants were 224 adults with ACPA/RF-positive RA who were
randomly assigned to either NLC or rheumatologist-led care
(RLC). The primary outcome was the Disease Activity Score in 28
Joints measured with C reactive protein (DAS28-CRP) assessed at
baseline and after 3, 6, 9 and 12 months. A DAS28-CRP difference
of 0.6 was set as the non-inferiority margin. Mean differences
between the groups were assessed following per-protocol and intention-to-treat strategies. RESULTS: Demographic data and baseline characteristics of patients in the NLC group (n=111) were comparable to those of patients in the RLC group (n=113).
The improvement in disease activity (change in DAS28-CRP,
primary outcome) over the course of 12 months was significant in both groups (p<0.001). No significant differences were observed between the NLC and RLC groups (p=0.317). Non-inferiority of NLC
was shown for the primary outcome and all secondary outcomes.
CONCLUSION: This study supported the non-inferiority of NLC in
managing T2T and follow-up care of patients with RA with
moderate to high disease activity and poor prognostic factors in
addition to RLC. TRIAL REGISTRATION NUMBER: DRKS00013055."},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
ÖBJECTIVE: To determine the non-inferiority of nurse-led care
(NLC) in patients with anticitrullinated protein antibody
(ACPA)-positive and/or rheumatoid factor (RF)-positive
rheumatoid arthritis (RA) with active disease who are starting
disease-modifying antirheumatic drug therapy, following
treat-to-target (T2T) recommendations. METHODS: A multicentre,
pragmatic randomised controlled trial was conducted to assess
clinical effectiveness, anxiety, depression and patient
satisfaction following a non-inferiority design. The
participants were 224 adults with ACPA/RF-positive RA who were
randomly assigned to either NLC or rheumatologist-led care
(RLC). The primary outcome was the Disease Activity Score in 28
Joints measured with C reactive protein (DAS28-CRP) assessed at
baseline and after 3, 6, 9 and 12 months. A DAS28-CRP difference
of 0.6 was set as the non-inferiority margin. Mean differences
between the groups were assessed following per-protocol and intention-to-treat strategies. RESULTS: Demographic data and baseline characteristics of patients in the NLC group (n=111) were comparable to those of patients in the RLC group (n=113).
The improvement in disease activity (change in DAS28-CRP,
primary outcome) over the course of 12 months was significant in both groups (p<0.001). No significant differences were observed between the NLC and RLC groups (p=0.317). Non-inferiority of NLC
was shown for the primary outcome and all secondary outcomes.
CONCLUSION: This study supported the non-inferiority of NLC in
managing T2T and follow-up care of patients with RA with
moderate to high disease activity and poor prognostic factors in
addition to RLC. TRIAL REGISTRATION NUMBER: DRKS00013055." |
Englbrecht, M.; Bartz-Bazzanella, P.; Decken, C.; Gauler, G.; Wurth, P.; Aries, P.; Karberg, K.; Kuhn, C.; Schuch, F.; Spathling-Mestekemper, S.; Vorbruggen, W.; Wendler, J.; Welcker, M.; Kleinert, S.: Prevalence of Depressive Symptoms in Patients With Psoriatic Arthritis: Have Numbers Changed During the COVID-19 Pandemic?. In: Front Med (Lausanne), Bd. 8, S. 748262, 2021, ISSN: 2296-858X (Print)
2296-858X (Linking). @article{RN9958,
title = {Prevalence of Depressive Symptoms in Patients With Psoriatic Arthritis: Have Numbers Changed During the COVID-19 Pandemic?},
author = {M. Englbrecht and P. Bartz-Bazzanella and C. Decken and G. Gauler and P. Wurth and P. Aries and K. Karberg and C. Kuhn and F. Schuch and S. Spathling-Mestekemper and W. Vorbruggen and J. Wendler and M. Welcker and S. Kleinert},
url = {https://www.ncbi.nlm.nih.gov/pubmed/34790678
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8591045/pdf/fmed-08-748262.pdf},
doi = {10.3389/fmed.2021.748262},
issn = {2296-858X (Print)
2296-858X (Linking)},
year = {2021},
date = {2021-01-01},
journal = {Front Med (Lausanne)},
volume = {8},
pages = {748262},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
|
Kleinert, S.; Rapp, P.; Schuch, F.; Ronneberger, M.; Wendler, J.; Sternad, P.; Popp, F.; Bartz-Bazzanella, P.; Decken, C. B. Von; Karberg, K.; Gauler, G.; Wurth, P.; Spaethling-Mestekemper, S.; Kuhn, C.; Englbrecht, M.; Vorbrüggen, W.; Adler, G.; Welcker, M.: Cognitive Impairment in axial spondyloarthritis? [abstract]. In: Annals of the Rheumatic Diseases, Bd. 80, Nr. Suppl 1, S. 1274, 2021. @article{RN9667,
title = {Cognitive Impairment in axial spondyloarthritis? [abstract]},
author = {S. Kleinert and P. Rapp and F. Schuch and M. Ronneberger and J. Wendler and P. Sternad and F. Popp and P. Bartz-Bazzanella and C. B. Von Decken and K. Karberg and G. Gauler and P. Wurth and S. Spaethling-Mestekemper and C. Kuhn and M. Englbrecht and W. Vorbrüggen and G. Adler and M. Welcker},
url = {http://ard.bmj.com/content/80/Suppl_1/1274.abstract
https://ard.bmj.com/content/annrheumdis/80/Suppl_1/1274.full.pdf},
doi = {10.1136/annrheumdis-2021-eular.1353},
year = {2021},
date = {2021-01-01},
journal = {Annals of the Rheumatic Diseases},
volume = {80},
number = {Suppl 1},
pages = {1274},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
|
Kleinert, Stefan; Schuch, Florian; Rapp, Praxedis; Ronneberger, Monika; Wendler, Joerg; Englbrecht, Matthias: How many of your patients have depressive symptoms? How to assess during routine clinical practice?. In: Ann Rheum Dis, Bd. 78, S. A638, 2019. @article{RN9615,
title = {How many of your patients have depressive symptoms? How to assess during routine clinical practice?},
author = {Stefan Kleinert and Florian Schuch and Praxedis Rapp and Monika Ronneberger and Joerg Wendler and Matthias Englbrecht},
year = {2019},
date = {2019-01-01},
journal = {Ann Rheum Dis},
volume = {78},
pages = {A638},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
|
Kleinert, Stefan; Rapp, Praxedis; Ronneberger, Monika; Wendler, Joerg; Schuch, Florian: Dealing with comorbidities in rheumatoid arthritis with medical assistants. The patients’ opinion on assessment and education by medical assistants during routine clinical practice [abstract]. In: Ann Rheum Dis, Bd. 78, supplement 2, 2019. @article{RN9625,
title = {Dealing with comorbidities in rheumatoid arthritis with medical assistants. The patients’ opinion on assessment and education by medical assistants during routine clinical practice [abstract]},
author = {Stefan Kleinert and Praxedis Rapp and Monika Ronneberger and Joerg Wendler and Florian Schuch},
year = {2019},
date = {2019-01-01},
journal = {Ann Rheum Dis},
volume = {78, supplement 2},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
|
Englbrecht, Matthias; Alten, Rieke; Aringer, Martin; Baerwald, Christoph G.; Burkhardt, Harald; Eby, Nancy; Flacke, Jan-Paul; Fliedner, Gerhard; Henkemeier, Ulf; Hofmann, Michael W.; Kleinert, Stefan; Kneitz, Christian; Krüger, Klaus; Pohl, Christoph; Schett, Georg; Schmalzing, Marc; Tausche, Anne-Kathrin; Tony, Hans-Peter; Wendler, Jörg: New insights into the prevalence of depressive symptoms and depression in rheumatoid arthritis – Implications from the prospective multicenter VADERA II study. In: PLOS ONE, Bd. 14, Nr. 5, S. e0217412, 2019. @article{RN9063,
title = {New insights into the prevalence of depressive symptoms and depression in rheumatoid arthritis – Implications from the prospective multicenter VADERA II study},
author = {Matthias Englbrecht and Rieke Alten and Martin Aringer and Christoph G. Baerwald and Harald Burkhardt and Nancy Eby and Jan-Paul Flacke and Gerhard Fliedner and Ulf Henkemeier and Michael W. Hofmann and Stefan Kleinert and Christian Kneitz and Klaus Krüger and Christoph Pohl and Georg Schett and Marc Schmalzing and Anne-Kathrin Tausche and Hans-Peter Tony and Jörg Wendler},
url = {https://doi.org/10.1371/journal.pone.0217412},
doi = {10.1371/journal.pone.0217412},
year = {2019},
date = {2019-01-01},
journal = {PLOS ONE},
volume = {14},
number = {5},
pages = {e0217412},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
|
Figueiredo, Camille P; Bang, Holger; Cobra, Jayme Fogagnolo; Englbrecht, Matthias; Hueber, Axel J; Haschka, Judith; Manger, Bernhard; Kleyer, Arnd; Reiser, Michaela; Finzel, Stephanie; Tony, Hans-Peter; Kleinert, Stefan; Wendler, Joerg; Schuch, Florian; Ronneberger, Monika; Feuchtenberger, Martin; Fleck, Martin; Manger, Karin; Ochs, Wolfgang; Schmitt-Haendle, Matthias; Lorenz, Hanns-Martin; Nuesslein, Hubert; Alten, Rieke; Henes, Joerg; Krueger, Klaus; Rech, Jürgen; Schett, Georg: Antimodified protein antibody response pattern influences the risk for disease relapse in patients with rheumatoid arthritis tapering disease modifying antirheumatic drugs. In: Ann. Rheum. Dis., Bd. 76, Nr. 2, S. 399–407, 2017. @article{Figueiredo2017-hw,
title = {Antimodified protein antibody response pattern influences the risk for disease relapse in patients with rheumatoid arthritis tapering disease modifying antirheumatic drugs},
author = {Camille P Figueiredo and Holger Bang and Jayme Fogagnolo Cobra and Matthias Englbrecht and Axel J Hueber and Judith Haschka and Bernhard Manger and Arnd Kleyer and Michaela Reiser and Stephanie Finzel and Hans-Peter Tony and Stefan Kleinert and Joerg Wendler and Florian Schuch and Monika Ronneberger and Martin Feuchtenberger and Martin Fleck and Karin Manger and Wolfgang Ochs and Matthias Schmitt-Haendle and Hanns-Martin Lorenz and Hubert Nuesslein and Rieke Alten and Joerg Henes and Klaus Krueger and Jürgen Rech and Georg Schett},
year = {2017},
date = {2017-02-01},
urldate = {2017-02-01},
journal = {Ann. Rheum. Dis.},
volume = {76},
number = {2},
pages = {399–407},
abstract = {ÖBJECTIVE: To perform a detailed analysis of the autoantibody
response against post-translationally modified proteins in
patients with rheumatoid arthritis (RA) in sustained remission
and to explore whether its composition influences the risk for
disease relapse when tapering disease modifying antirheumatic
drug (DMARD) therapy. METHODS: Immune responses against 10
citrullinated, homocitrullinated/carbamylated and acetylated
peptides, as well as unmodified vimentin (control) and cyclic
citrullinated peptide 2 (CCP2) were tested in baseline serum
samples from 94 patients of the RETRO study. Patients were
classified according to the number of autoantibody reactivities
(0-1/10, 2-5/10 and >5/10) or specificity groups (citrullination,
carbamylation and acetylation; 0-3) and tested for their risk to
develop relapses after DMARD tapering. Demographic and
disease-specific parameters were included in multivariate
logistic regression analysis for defining the role of
autoantibodies in predicting relapse. RESULTS: Patients varied in
their antimodified protein antibody response with the extremes
from recognition of no (0/10) to all antigens (10/10). Antibodies
against citrullinated vimentin (51%), acetylated ornithine (46%) and acetylated lysine (37%) were the most frequently observed subspecificities. Relapse risk significantly (p=0.011)
increased from 18% (0-1/10 reactivities) to 34% (2-5/10) and 55% (>5/10). With respect to specificity groups (0-3), relapse risk significantly (p=0.021) increased from 18% (no reactivity)
to 28%, 36% and finally to 52% with one, two or three antibody
specificity groups, respectively. CONCLUSIONS: The data suggest
that the pattern of antimodified protein antibody response
determines the risk of disease relapse in patients with RA
tapering DMARD therapy. TRIAL REGISTRATION NUMBER:
2009-015740-42; Results."},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
ÖBJECTIVE: To perform a detailed analysis of the autoantibody
response against post-translationally modified proteins in
patients with rheumatoid arthritis (RA) in sustained remission
and to explore whether its composition influences the risk for
disease relapse when tapering disease modifying antirheumatic
drug (DMARD) therapy. METHODS: Immune responses against 10
citrullinated, homocitrullinated/carbamylated and acetylated
peptides, as well as unmodified vimentin (control) and cyclic
citrullinated peptide 2 (CCP2) were tested in baseline serum
samples from 94 patients of the RETRO study. Patients were
classified according to the number of autoantibody reactivities
(0-1/10, 2-5/10 and >5/10) or specificity groups (citrullination,
carbamylation and acetylation; 0-3) and tested for their risk to
develop relapses after DMARD tapering. Demographic and
disease-specific parameters were included in multivariate
logistic regression analysis for defining the role of
autoantibodies in predicting relapse. RESULTS: Patients varied in
their antimodified protein antibody response with the extremes
from recognition of no (0/10) to all antigens (10/10). Antibodies
against citrullinated vimentin (51%), acetylated ornithine (46%) and acetylated lysine (37%) were the most frequently observed subspecificities. Relapse risk significantly (p=0.011)
increased from 18% (0-1/10 reactivities) to 34% (2-5/10) and 55% (>5/10). With respect to specificity groups (0-3), relapse risk significantly (p=0.021) increased from 18% (no reactivity)
to 28%, 36% and finally to 52% with one, two or three antibody
specificity groups, respectively. CONCLUSIONS: The data suggest
that the pattern of antimodified protein antibody response
determines the risk of disease relapse in patients with RA
tapering DMARD therapy. TRIAL REGISTRATION NUMBER:
2009-015740-42; Results." |
Englbrecht, M.; Alten, R.; Aringer, M.; Baerwald, C. G.; Burkhardt, H.; Eby, N.; Fliedner, G.; Gauger, B.; Henkemeier, U.; Hofmann, M. W.; Kleinert, S.; Kneitz, C.; Krueger, K.; Pohl, C.; Roske, A. E.; Schett, G.; Schmalzing, M.; Tausche, A. K.; Tony, H. Peter; Wendler, J.: Validation of Standardized Questionnaires Evaluating Symptoms of Depression in Rheumatoid Arthritis Patients: Approaches to Screening for a Frequent Yet Underrated Challenge. In: Arthritis Care Res (Hoboken), Bd. 69, Nr. 1, S. 58-66, 2017, ISSN: 2151-4658 (Electronic)
2151-464X (Linking). @article{RN8198,
title = {Validation of Standardized Questionnaires Evaluating Symptoms of Depression in Rheumatoid Arthritis Patients: Approaches to Screening for a Frequent Yet Underrated Challenge},
author = {M. Englbrecht and R. Alten and M. Aringer and C. G. Baerwald and H. Burkhardt and N. Eby and G. Fliedner and B. Gauger and U. Henkemeier and M. W. Hofmann and S. Kleinert and C. Kneitz and K. Krueger and C. Pohl and A. E. Roske and G. Schett and M. Schmalzing and A. K. Tausche and H. Peter Tony and J. Wendler},
url = {https://www.ncbi.nlm.nih.gov/pubmed/27482854 http://onlinelibrary.wiley.com/store/10.1002/acr.23002/asset/acr23002.pdf?v=1&t=j4e9fhol&s=713b86ce15fe37f619af80435413e786b0ac549f},
doi = {10.1002/acr.23002},
issn = {2151-4658 (Electronic)
2151-464X (Linking)},
year = {2017},
date = {2017-01-01},
journal = {Arthritis Care Res (Hoboken)},
volume = {69},
number = {1},
pages = {58-66},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
|
Figueiredo, C. P.; Bang, H.; Cobra, J. F.; Englbrecht, M.; Hueber, A. J.; Haschka, J.; Manger, B.; Kleyer, A.; Reiser, M.; Finzel, S.; Tony, H. P.; Kleinert, S.; Wendler, J.; Schuch, F.; Ronneberger, M.; Feuchtenberger, M.; Fleck, M.; Manger, K.; Ochs, W.; Schmitt-Haendle, M.; Lorenz, H. M.; Nuesslein, H.; Alten, R.; Henes, J.; Krueger, K.; Rech, J.; Schett, G.: Antimodified protein antibody response pattern influences the risk for disease relapse in patients with rheumatoid arthritis tapering disease modifying antirheumatic drugs. In: Ann Rheum Dis, Bd. 76, Nr. 2, S. 399-407, 2017, ISSN: 1468-2060 (Electronic)
0003-4967 (Linking). @article{RN8609,
title = {Antimodified protein antibody response pattern influences the risk for disease relapse in patients with rheumatoid arthritis tapering disease modifying antirheumatic drugs},
author = {C. P. Figueiredo and H. Bang and J. F. Cobra and M. Englbrecht and A. J. Hueber and J. Haschka and B. Manger and A. Kleyer and M. Reiser and S. Finzel and H. P. Tony and S. Kleinert and J. Wendler and F. Schuch and M. Ronneberger and M. Feuchtenberger and M. Fleck and K. Manger and W. Ochs and M. Schmitt-Haendle and H. M. Lorenz and H. Nuesslein and R. Alten and J. Henes and K. Krueger and J. Rech and G. Schett},
url = {https://www.ncbi.nlm.nih.gov/pubmed/27323772
http://ard.bmj.com/content/annrheumdis/76/2/399.full.pdf},
doi = {10.1136/annrheumdis-2016-209297},
issn = {1468-2060 (Electronic)
0003-4967 (Linking)},
year = {2017},
date = {2017-01-01},
journal = {Ann Rheum Dis},
volume = {76},
number = {2},
pages = {399-407},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
|
Englbrecht, Matthias; Alten, Rieke; Aringer, Martin; Baerwald, Christoph G.; Burkhardt, Harald; Eby, Nancy; Fliedner, Gerhard; Gauger, Bettina; Henkemeier, Ulf; Hofmann, Michael W.; Kleinert, Stefan; Kneitz, Christian; Krueger, Klaus; Pohl, Christoph; Roske, Anne-Eve; Schett, Georg; Schmalzing, Marc; Tausche, Anne-Kathrin; Tony, Hans Peter; Wendler, Joerg: Validation of standardized questionnaires evaluating symptoms of depression in rheumatoid arthritis patients - approaches to screening for a frequent and yet underrated challenge. In: Arthritis Care & Research, S. n/a-n/a, 2016, ISSN: 2151-4658. @article{RN9108,
title = {Validation of standardized questionnaires evaluating symptoms of depression in rheumatoid arthritis patients - approaches to screening for a frequent and yet underrated challenge},
author = {Matthias Englbrecht and Rieke Alten and Martin Aringer and Christoph G. Baerwald and Harald Burkhardt and Nancy Eby and Gerhard Fliedner and Bettina Gauger and Ulf Henkemeier and Michael W. Hofmann and Stefan Kleinert and Christian Kneitz and Klaus Krueger and Christoph Pohl and Anne-Eve Roske and Georg Schett and Marc Schmalzing and Anne-Kathrin Tausche and Hans Peter Tony and Joerg Wendler},
url = {https://onlinelibrary.wiley.com/doi/pdf/10.1002/acr.23002},
doi = {10.1002/acr.23002},
issn = {2151-4658},
year = {2016},
date = {2016-01-01},
journal = {Arthritis Care & Research},
pages = {n/a-n/a},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
|
Haschka, J.; Englbrecht, M.; Hueber, A. J.; Manger, B.; Kleyer, A.; Reiser, M.; Finzel, S.; Tony, H. P.; Kleinert, S.; Feuchtenberger, M.; Fleck, M.; Manger, K.; Ochs, W.; Schmitt-Haendle, M.; Wendler, J.; Schuch, F.; Ronneberger, M.; Lorenz, H. M.; Nuesslein, H.; Alten, R.; Demary, W.; Henes, J.; Schett, G.; Rech, J.: Relapse rates in patients with rheumatoid arthritis in stable remission tapering or stopping antirheumatic therapy: interim results from the prospective randomised controlled RETRO study. In: Ann Rheum Dis, Bd. 75, Nr. 1, S. 45-51, 2016, ISSN: 1468-2060 (Electronic)
0003-4967 (Linking). @article{RN7751,
title = {Relapse rates in patients with rheumatoid arthritis in stable remission tapering or stopping antirheumatic therapy: interim results from the prospective randomised controlled RETRO study},
author = {J. Haschka and M. Englbrecht and A. J. Hueber and B. Manger and A. Kleyer and M. Reiser and S. Finzel and H. P. Tony and S. Kleinert and M. Feuchtenberger and M. Fleck and K. Manger and W. Ochs and M. Schmitt-Haendle and J. Wendler and F. Schuch and M. Ronneberger and H. M. Lorenz and H. Nuesslein and R. Alten and W. Demary and J. Henes and G. Schett and J. Rech},
url = {http://www.ncbi.nlm.nih.gov/pubmed/25660991},
doi = {10.1136/annrheumdis-2014-206439},
issn = {1468-2060 (Electronic)
0003-4967 (Linking)},
year = {2016},
date = {2016-01-01},
journal = {Ann Rheum Dis},
volume = {75},
number = {1},
pages = {45-51},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
|
Kleinert, S.; Waldner, M.; Wendler, J.; Kunzmann, V.: [Disease-modifying antirheumatic drugs in rheumatoid arthritis patients with a history of colorectal cancer]. In: Z Rheumatol, Bd. 75, Nr. 1, S. 41-6, 2016, ISSN: 1435-1250 (Electronic)
0340-1855 (Linking). @article{RN8064,
title = {[Disease-modifying antirheumatic drugs in rheumatoid arthritis patients with a history of colorectal cancer]},
author = {S. Kleinert and M. Waldner and J. Wendler and V. Kunzmann},
url = {http://www.ncbi.nlm.nih.gov/pubmed/26786168 http://download.springer.com/static/pdf/163/art%253A10.1007%252Fs00393-015-0032-8.pdf?originUrl=http%3A%2F%2Flink.springer.com%2Farticle%2F10.1007%2Fs00393-015-0032-8&token2=exp=1456567687~acl=%2Fstatic%2Fpdf%2F163%2Fart%25253A10.1007%25252Fs00393-015-0032-8.pdf%3ForiginUrl%3Dhttp%253A%252F%252Flink.springer.com%252Farticle%252F10.1007%252Fs00393-015-0032-8*~hmac=22a15e98f1b4a995584b830b445c6680f14e09356e23796ba3df76a7f0d4004b},
doi = {10.1007/s00393-015-0032-8},
issn = {1435-1250 (Electronic)
0340-1855 (Linking)},
year = {2016},
date = {2016-01-01},
journal = {Z Rheumatol},
volume = {75},
number = {1},
pages = {41-6},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
|
Rech, J.; Hueber, A. J.; Finzel, S.; Englbrecht, M.; Haschka, J.; Manger, B.; Kleyer, A.; Reiser, M.; Cobra, J. F.; Figueiredo, C.; Tony, H. P.; Kleinert, S.; Wendler, J.; Schuch, F.; Ronneberger, M.; Feuchtenberger, M.; Fleck, M.; Manger, K.; Ochs, W.; Schmitt-Haendle, M.; Lorenz, H. M.; Nuesslein, H.; Alten, R.; Henes, J.; Krueger, K.; Schett, G.: Prediction of disease relapses by multibiomarker disease activity and autoantibody status in patients with rheumatoid arthritis on tapering DMARD treatment. In: Ann Rheum Dis, Bd. 75, Nr. 9, S. 1637-44, 2016, ISSN: 1468-2060 (Electronic)
0003-4967 (Linking). @article{RN8206,
title = {Prediction of disease relapses by multibiomarker disease activity and autoantibody status in patients with rheumatoid arthritis on tapering DMARD treatment},
author = {J. Rech and A. J. Hueber and S. Finzel and M. Englbrecht and J. Haschka and B. Manger and A. Kleyer and M. Reiser and J. F. Cobra and C. Figueiredo and H. P. Tony and S. Kleinert and J. Wendler and F. Schuch and M. Ronneberger and M. Feuchtenberger and M. Fleck and K. Manger and W. Ochs and M. Schmitt-Haendle and H. M. Lorenz and H. Nuesslein and R. Alten and J. Henes and K. Krueger and G. Schett},
url = {https://www.ncbi.nlm.nih.gov/pubmed/26483255
http://ard.bmj.com/content/annrheumdis/75/9/1637.full.pdf},
doi = {10.1136/annrheumdis-2015-207900},
issn = {1468-2060 (Electronic)
0003-4967 (Linking)},
year = {2016},
date = {2016-01-01},
journal = {Ann Rheum Dis},
volume = {75},
number = {9},
pages = {1637-44},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
|
Haschka, J.; Englbrecht, M.; Hueber, A. J.; Manger, B.; Kleyer, A.; Reiser, M.; Finzel, S.; Tony, H. P.; Kleinert, S.; Feuchtenberger, M.; Fleck, M.; Manger, K.; Ochs, W.; Schmitt-Haendle, M.; Wendler, J.; Schuch, F.; Ronneberger, M.; Lorenz, H. M.; Nuesslein, H.; Alten, R.; Demary, W.; Henes, J.; Schett, G.; Rech, J.: Relapse rates in patients with rheumatoid arthritis in stable remission tapering or stopping antirheumatic therapy: interim results from the prospective randomised controlled RETRO study. In: Ann Rheum Dis, 2015, ISSN: 0003-4967. @article{RN9102,
title = {Relapse rates in patients with rheumatoid arthritis in stable remission tapering or stopping antirheumatic therapy: interim results from the prospective randomised controlled RETRO study},
author = {J. Haschka and M. Englbrecht and A. J. Hueber and B. Manger and A. Kleyer and M. Reiser and S. Finzel and H. P. Tony and S. Kleinert and M. Feuchtenberger and M. Fleck and K. Manger and W. Ochs and M. Schmitt-Haendle and J. Wendler and F. Schuch and M. Ronneberger and H. M. Lorenz and H. Nuesslein and R. Alten and W. Demary and J. Henes and G. Schett and J. Rech},
url = {https://ard.bmj.com/content/annrheumdis/75/1/45.full.pdf},
doi = {10.1136/annrheumdis-2014-206439},
issn = {0003-4967},
year = {2015},
date = {2015-01-01},
journal = {Ann Rheum Dis},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
|
Englbrecht, M.; Alten, R.; Aringer, M.; Baerwald, CG.; Burkhardt, H.; Eby, N.; Fliedner, G.; Gauger, B.; Henkemeier, U.; Hofmann, M.; Kleinert, S.; Kneitz, C.; Pohl, C.; Schett, G.; Schmalzing, M.; Tausche, A.; Tony, H.; Wendler, J.: Evaluating Depression Questionnaires In German Rheumatoid Arthritis Patients – Preliminary Results From a Validation Study. In: Arthritis Rheum, Bd. 65, Nr. Suppl 10, S. 978, 2013. @article{RN7756,
title = {Evaluating Depression Questionnaires In German Rheumatoid Arthritis Patients – Preliminary Results From a Validation Study},
author = {M. Englbrecht and R. Alten and M. Aringer and CG. Baerwald and H. Burkhardt and N. Eby and G. Fliedner and B. Gauger and U. Henkemeier and M. Hofmann and S. Kleinert and C. Kneitz and C. Pohl and G. Schett and M. Schmalzing and A. Tausche and H. Tony and J. Wendler},
year = {2013},
date = {2013-01-01},
journal = {Arthritis Rheum},
volume = {65},
number = {Suppl 10},
pages = {978},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
|